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TitleNovel Pyrrole Carboxamide Inhibitors of Jak2 as Potential Treatment of Myeloproliferative Disorders.
Journal, issue, pagesBioorg. Med. Chem., Vol. 23, Page 2387-, Year 2015
Publish dateJan 8, 2015 (structure data deposition date)
AuthorsBrasca, M.G. / Gnocchi, P. / Nesi, M. / Amboldi, N. / Avanzi, N. / Bertrand, J. / Bindi, S. / Canevari, G. / Casero, D. / Ciomei, M. ...Brasca, M.G. / Gnocchi, P. / Nesi, M. / Amboldi, N. / Avanzi, N. / Bertrand, J. / Bindi, S. / Canevari, G. / Casero, D. / Ciomei, M. / Colombo, N. / Cribioli, S. / Fachin, G. / Felder, E.R. / Galvani, A. / Isacchi, A. / Motto, I. / Panzeri, A. / Donati, D.
External linksBioorg. Med. Chem. / PubMed:25882525
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-5aep:
Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-QUP:
1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1H-pyrrole-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PROTEIN KINASE / JAK2 / MYELOPROLIFERATIVE DISORDERS / TUMOUR CELL PROLIFERATION INHIBITION / ANTI-CANCER AGENTS

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