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TitleSelective Inhibitors of the Protein Tyrosine Phosphatase Shp2 Block Cellular Motility and Growth of Cancer Cells in Vitro and in Vivo.
Journal, issue, pagesChemmedchem, Vol. 10, Page 815-, Year 2015
Publish dateFeb 4, 2013 (structure data deposition date)
AuthorsGrosskopf, S. / Eckert, C. / Arkona, C. / Radetzki, S. / Bohm, K. / Heinemann, U. / Wolber, G. / Von Kries, J. / Birchmeier, W. / Rademann, J.
External linksChemmedchem / PubMed:25877780
MethodsX-ray diffraction
Resolution1.4 - 1.5 Å
Structure data

PDB-3zm0:
Catalytic domain of human SHP2
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-3zm1:
Catalytic domain of human SHP2
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-3zm2:
Catalytic domain of human SHP2
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-3zm3:
Catalytic domain of human SHP2
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PTP1B

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