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TitleTranslational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
Journal, issue, pagesOsteoarthr. Cartil., Vol. 23, Page 1254-1266, Year 2015
Publish dateDec 9, 2014 (structure data deposition date)
AuthorsLarkin, J. / Lohr, T.A. / Elefante, L. / Shearin, J. / Matico, R. / Su, J.L. / Xue, Y. / Liu, F. / Genell, C. / Miller, R.E. ...Larkin, J. / Lohr, T.A. / Elefante, L. / Shearin, J. / Matico, R. / Su, J.L. / Xue, Y. / Liu, F. / Genell, C. / Miller, R.E. / Tran, P.B. / Malfait, A.M. / Maier, C.C. / Matheny, C.J.
External linksOsteoarthr. Cartil. / PubMed:25800415
MethodsX-ray diffraction
Resolution2.35 - 2.6 Å
Structure data

PDB-4x80:
Crystal Structure of murine 7B4 Fab monoclonal antibody against ADAMTS5
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-4x8j:
Crystal Structure of murine 12F4 Fab monoclonal antibody against ADAMTS5
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-2PE:
NONAETHYLENE GLYCOL / precipitant*YM

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / monoclonal

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