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-Structure paper
Title | Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 3572-3581, Year 2015 |
Publish date | Feb 26, 2013 (structure data deposition date) |
Authors | Salo-Ahen, O.M. / Tochowicz, A. / Pozzi, C. / Cardinale, D. / Ferrari, S. / Boum, Y. / Mangani, S. / Stroud, R.M. / Saxena, P. / Myllykallio, H. ...Salo-Ahen, O.M. / Tochowicz, A. / Pozzi, C. / Cardinale, D. / Ferrari, S. / Boum, Y. / Mangani, S. / Stroud, R.M. / Saxena, P. / Myllykallio, H. / Costi, M.P. / Ponterini, G. / Wade, R.C. |
External links | J. Med. Chem. / PubMed:25798950 |
Methods | X-ray diffraction |
Resolution | 2.03 - 2.311 Å |
Structure data | PDB-4jef: PDB-4kpw: |
Chemicals | ChemComp-SO4: ChemComp-HOH: ChemComp-EDO: |
Source |
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Keywords | TRANSFERASE / Inactive form of human thymidylate synthase / hot spot residue / interface hot spot / METHYLTRANSFERASE / NUCLEOTIDE BIOSYNTHESIS |