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TitleInvestigation of (E)-3-[4-(2-Oxo-3-Aryl-Chromen-4-Yl)Oxyphenyl]Acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators.
Journal, issue, pagesJ. Med. Chem., Vol. 58, Page 3522-, Year 2015
Publish dateFeb 27, 2015 (structure data deposition date)
AuthorsDegorce, S.L. / Bailey, A. / Callis, R. / De Savi, C. / Ducray, R. / Lamont, G. / Macfaul, P. / Maudet, M. / Martin, S. / Morgentin, R. ...Degorce, S.L. / Bailey, A. / Callis, R. / De Savi, C. / Ducray, R. / Lamont, G. / Macfaul, P. / Maudet, M. / Martin, S. / Morgentin, R. / Norman, R.A. / Peru, A. / Pink, J.H. / Ple, P.A. / Roberts, B. / Scott, J.S.
External linksJ. Med. Chem. / PubMed:25790336
MethodsX-ray diffraction
Resolution2.19 Å
Structure data

PDB-5ak2:
Oxyphenylpropenoic acids as Oral Selective Estrogen Receptor Down- Regulators.
Method: X-RAY DIFFRACTION / Resolution: 2.19 Å

Chemicals

ChemComp-85Z:
(E)-3-[4-[[3-(4-fluoranyl-2-methyl-phenyl)-7-oxidanyl-2-oxidanylidene-chromen-4-yl]methyl]phenyl]prop-2-enoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN

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