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TitleTyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 11061-11074, Year 2015
Publish dateOct 16, 2014 (structure data deposition date)
AuthorsTokarski, J.S. / Zupa-Fernandez, A. / Tredup, J.A. / Pike, K. / Chang, C. / Xie, D. / Cheng, L. / Pedicord, D. / Muckelbauer, J. / Johnson, S.R. ...Tokarski, J.S. / Zupa-Fernandez, A. / Tredup, J.A. / Pike, K. / Chang, C. / Xie, D. / Cheng, L. / Pedicord, D. / Muckelbauer, J. / Johnson, S.R. / Wu, S. / Edavettal, S.C. / Hong, Y. / Witmer, M.R. / Elkin, L.L. / Blat, Y. / Pitts, W.J. / Weinstein, D.S. / Burke, J.R.
External linksJ. Biol. Chem. / PubMed:25762719
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4wov:
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH BMS-066 AKA 2-METHOXY-N-({6-[3-METHYL-7-(METHYLAMINO)-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0, 6]DODECA-1(9),2(6),4,7,11-PENTAEN-11-YL]PYRIDIN-2-YL}METHY L)ACETAMIDE
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-3SM:
2-methoxy-N-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / KINASE / TYK2 / PSEUDOKINASE / TRANSFERASE-INHIBITOR complex

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