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Structure paper

TitleCrystal structures of immunoglobulin Fc heterodimers reveal the molecular basis for heterodimer formation.
Journal, issue, pagesMol. Immunol., Vol. 65, Page 377-383, Year 2015
Publish dateDec 11, 2014 (structure data deposition date)
AuthorsChoi, H.J. / Seok, S.H. / Kim, Y.J. / Seo, M.D. / Kim, Y.S.
External linksMol. Immunol. / PubMed:25743157
MethodsX-ray diffraction
Resolution2.498 - 2.499 Å
Structure data

PDB-4x98:
Immunoglobulin Fc heterodimer variant
Method: X-RAY DIFFRACTION / Resolution: 2.499 Å

PDB-4x99:
Immunoglobulin Fc heterodimers variant
Method: X-RAY DIFFRACTION / Resolution: 2.498 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / bispecific antibody / immunoglobulin Fc heterodimer / CH3 domain interface / asymmetric disulfide bonds / thermal stability / Fc engineering

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