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-Structure paper
Title | Pf-06463922 is a Potent and Selective Next-Generation Ros1/Alk Inhibitor Capable of Blocking Crizotinib-Resistant Ros1 Mutations. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 112, Page 3493-, Year 2015 |
Publish date | Aug 25, 2014 (structure data deposition date) |
![]() | Zou, H.Y. / Li, Q. / Engstrom, L.D. / West, M. / Appleman, V. / Wong, K.A. / Mctigue, M. / Deng, Y. / Liu, W. / Brooun, A. ...Zou, H.Y. / Li, Q. / Engstrom, L.D. / West, M. / Appleman, V. / Wong, K.A. / Mctigue, M. / Deng, Y. / Liu, W. / Brooun, A. / Timofeevski, S. / Mcdonnell, S.R.P. / Jiang, P. / Falk, M.D. / Lappin, P.B. / Affolter, T. / Nichols, T. / Hu, W. / Lam, J. / Johnson, T.W. / Smeal, T. / Charest, A. / Fantin, V.R. |
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Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | ![]() PDB-4uxl: |
Chemicals | ![]() ChemComp-5P8: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / INHIBITOR / ROS |