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TitleMechanism of human antibody-mediated neutralization of Marburg virus.
Journal, issue, pagesCell, Vol. 160, Issue 5, Page 893-903, Year 2015
Publish dateFeb 26, 2015
AuthorsAndrew I Flyak / Philipp A Ilinykh / Charles D Murin / Tania Garron / Xiaoli Shen / Marnie L Fusco / Takao Hashiguchi / Zachary A Bornholdt / James C Slaughter / Gopal Sapparapu / Curtis Klages / Thomas G Ksiazek / Andrew B Ward / Erica Ollmann Saphire / Alexander Bukreyev / James E Crowe /
PubMed AbstractThe mechanisms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known. We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to MARV glycoprotein ...The mechanisms by which neutralizing antibodies inhibit Marburg virus (MARV) are not known. We isolated a panel of neutralizing antibodies from a human MARV survivor that bind to MARV glycoprotein (GP) and compete for binding to a single major antigenic site. Remarkably, several of the antibodies also bind to Ebola virus (EBOV) GP. Single-particle EM structures of antibody-GP complexes reveal that all of the neutralizing antibodies bind to MARV GP at or near the predicted region of the receptor-binding site. The presence of the glycan cap or mucin-like domain blocks binding of neutralizing antibodies to EBOV GP, but not to MARV GP. The data suggest that MARV-neutralizing antibodies inhibit virus by binding to infectious virions at the exposed MARV receptor-binding site, revealing a mechanism of filovirus inhibition.
External linksCell / PubMed:25723164 / PubMed Central
MethodsEM (single particle)
Resolution22.0 - 27.0 Å
Structure data

EMDB-6232:
Negative stain single particle electron microscopy of Marburg Virus Glycoproteins bound to antibodies from a human survivor
Method: EM (single particle) / Resolution: 27.0 Å

EMDB-6233:
Negative stain single particle electron microscopy of Marburg Virus Glycoproteins bound to antibodies from a human survivor
Method: EM (single particle) / Resolution: 22.0 Å

EMDB-6234:
Negative stain single particle electron microscopy of Marburg Virus Glycoproteins bound to antibodies from a human survivor
Method: EM (single particle) / Resolution: 24.0 Å

EMDB-6235:
Negative stain single particle electron microscopy of Marburg Virus Glycoproteins bound to antibodies from a human survivor
Method: EM (single particle) / Resolution: 25.0 Å

EMDB-6236:
Negative stain single particle electron microscopy of Marburg Virus Glycoproteins bound to antibodies from a human survivor
Method: EM (single particle) / Resolution: 26.0 Å

EMDB-6237:
Negative stain single particle electron microscopy of Marburg Virus Glycoproteins bound to antibodies from a human survivor
Method: EM (single particle) / Resolution: 24.0 Å

EMDB-6238:
Negative stain single particle electron microscopy of Marburg Virus Glycoproteins bound to antibodies from a human survivor
Method: EM (single particle) / Resolution: 24.0 Å

Source
  • Marburg marburgvirus
  • Homo sapiens (human)

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