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TitleCharacterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Journal, issue, pagesBiochemistry, Vol. 54, Page 1918-1929, Year 2015
Publish dateMay 12, 2014 (structure data deposition date)
AuthorsKuai, J. / Mosyak, L. / Brooks, J. / Cain, M. / Carven, G.J. / Ogawa, S. / Ishino, T. / Tam, M. / Lavallie, E.R. / Yang, Z. ...Kuai, J. / Mosyak, L. / Brooks, J. / Cain, M. / Carven, G.J. / Ogawa, S. / Ishino, T. / Tam, M. / Lavallie, E.R. / Yang, Z. / Ponsel, D. / Rauchenberger, R. / Arch, R. / Pullen, N.
External linksBiochemistry / PubMed:25707433
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-4qci:
PDGF-B blocking antibody bound to PDGF-BB
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE/CYTOKINE RECEPTOR / growth factor cytokine fold / growth factor hormone / PDGFR-beta receptor / extracellular / CYTOKINE-CYTOKINE RECEPTOR complex

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