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TitleNovel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787.
Journal, issue, pagesOnco Targets Ther, Vol. 8, Page 375-383, Year 2015
Publish dateJun 19, 2014 (structure data deposition date)
AuthorsParker, A.R. / Petluru, P.N. / Nienaber, V.L. / Zhao, M. / Ayala, P.Y. / Badger, J. / Chie-Leon, B. / Sridhar, V. / Logan, C. / Kochat, H. / Hausheer, F.H.
External linksOnco Targets Ther / PubMed:25678804
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-4tt7:
Crystal structure of human ALK with a covalent modification
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-COM:
1-THIOETHANESULFONIC ACID

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ATP-BINDING / RECEPTOR

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