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TitleTargeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.
Journal, issue, pagesACS Chem Neurosci, Vol. 6, Page 666-680, Year 2015
Publish dateAug 14, 2014 (structure data deposition date)
AuthorsRoy, S.M. / Grum-Tokars, V.L. / Schavocky, J.P. / Saeed, F. / Staniszewski, A. / Teich, A.F. / Arancio, O. / Bachstetter, A.D. / Webster, S.J. / Van Eldik, L.J. ...Roy, S.M. / Grum-Tokars, V.L. / Schavocky, J.P. / Saeed, F. / Staniszewski, A. / Teich, A.F. / Arancio, O. / Bachstetter, A.D. / Webster, S.J. / Van Eldik, L.J. / Minasov, G. / Anderson, W.F. / Pelletier, J.C. / Watterson, D.M.
External linksACS Chem Neurosci / PubMed:25676389
MethodsX-ray diffraction
Resolution2.06 Å
Structure data

PDB-4r3c:
Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

ChemComp-GG5:
4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE

ChemComp-3GF:
6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Serine/Threonine-protein kinase / Protein Kinase Domain / Transferase / ATP Binding / Phosphorylation / Cytosol / TRANSFERASE-TRANSFERASE INHIBITOR complex

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