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-Structure paper
Title | Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. |
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Journal, issue, pages | Nat Commun, Vol. 6, Page 6263-6263, Year 2015 |
Publish date | Oct 21, 2014 (structure data deposition date) |
Authors | Rumpf, T. / Schiedel, M. / Karaman, B. / Roessler, C. / North, B.J. / Lehotzky, A. / Olah, J. / Ladwein, K.I. / Schmidtkunz, K. / Gajer, M. ...Rumpf, T. / Schiedel, M. / Karaman, B. / Roessler, C. / North, B.J. / Lehotzky, A. / Olah, J. / Ladwein, K.I. / Schmidtkunz, K. / Gajer, M. / Pannek, M. / Steegborn, C. / Sinclair, D.A. / Gerhardt, S. / Ovadi, J. / Schutkowski, M. / Sippl, W. / Einsle, O. / Jung, M. |
External links | Nat Commun / PubMed:25672491 |
Methods | X-ray diffraction |
Resolution | 1.42 - 1.88 Å |
Structure data | PDB-4rmg: PDB-4rmh: PDB-4rmi: PDB-4rmj: |
Chemicals | ChemComp-ZN: ChemComp-3TE: ChemComp-NAD: ChemComp-HOH: ChemComp-3TK: ChemComp-AR6: ChemComp-NCA: ChemComp-PEG: ChemComp-EDO: ChemComp-NA: ChemComp-PGE: |
Source |
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Keywords | Hydrolase/Hydrolase Inbititor / Hydrolase-Hydrolase Inbititor complex / Hydrolase/Hydrolase Inhibitor / Hydrolase-Hydrolase Inhibitor complex |