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TitleHapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies.
Journal, issue, pagesFaseb J., Vol. 29, Page 1763-1779, Year 2015
Publish dateJan 13, 2015 (structure data deposition date)
AuthorsDengl, S. / Hoffmann, E. / Grote, M. / Wagner, C. / Mundigl, O. / Georges, G. / Thorey, I. / Stubenrauch, K.G. / Bujotzek, A. / Josel, H.P. ...Dengl, S. / Hoffmann, E. / Grote, M. / Wagner, C. / Mundigl, O. / Georges, G. / Thorey, I. / Stubenrauch, K.G. / Bujotzek, A. / Josel, H.P. / Dziadek, S. / Benz, J. / Brinkmann, U.
External linksFaseb J. / PubMed:25670234
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-4s1d:
Structure of IgG1 Fab fragment in complex with Biotincytidinamide
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-41M:
N~6~-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}-L-lysinamide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Antibody / Fab fragment / hapten / MAB_M33_FAB_FRAGMENT

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