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Structure paper

TitleX-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
Journal, issue, pagesProteins, Vol. 83, Page 789-795, Year 2015
Publish dateNov 27, 2014 (structure data deposition date)
AuthorsDrinkwater, N. / Bamert, R.S. / Sivaraman, K.K. / Paiardini, A. / McGowan, S.
External linksProteins / PubMed:25645579
MethodsX-ray diffraction
Resolution1.5 - 2.729 Å
Structure data

PDB-4x2t:
X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M17 Leucyl Aminopeptidase from P. falciparum
Method: X-RAY DIFFRACTION / Resolution: 2.729 Å

PDB-4x2u:
X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M1 Alanyl Aminopeptidase from P. falciparum
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-TOD:
(2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid

ChemComp-CO3:
CARBONATE ION

ChemComp-SO4:
SULFATE ION

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • plasmodium falciparum (isolate 3d7) (eukaryote)
  • plasmodium falciparum fcb1/columbia (eukaryote)
KeywordsHydrolase/Hydrolase Inhibitor / M17 LEUCYL-AMINOPEPTIDASE / PROTEASE / INHIBITOR / TOSEDOSTAT / ANTIMALARIAL / PLASMODIUM FALCIPARUM / Hydrolase-Hydrolase Inhibitor complex / M1 ALANYL-AMINOPEPTIDASE

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