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Structure paper

TitleStudies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates.
Journal, issue, pagesEpigenetics, Vol. 9, Page 1596-, Year 2014
Publish dateOct 15, 2014 (structure data deposition date)
AuthorsWilliams, S.T. / Walport, L.J. / Hopkinson, R.J. / Madden, S.K. / Chowdhury, R. / Schofield, C.J. / Kawamura, A.
External linksEpigenetics / PubMed:25625844
MethodsX-ray diffraction
Resolution1.81 - 2 Å
Structure data

PDB-4v2v:
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-4v2w:
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (16-35)
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

Chemicals

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-NI:
NICKEL (II) ION

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / NON-HEME / IRON / 2-OXOGLUTARATE / DIOXYGENASE / OXYGENASE / DOUBLE-STRANDED BETA HELIX / DSBH / FACIAL TRIAD / JMJC DOMAIN / METAL BINDING PROTEIN / EPIGENETIC AND TRANSCRIPTION REGULATION / CHROMATIN REGULATOR / HYDROXYLATION / JMJD2A / DEMETHYLASE / HISTONE

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