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Structure paper

TitleStructure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 112, Page E576-E585, Year 2015
Publish dateDec 8, 2014 (structure data deposition date)
AuthorsSobhanifar, S. / Worrall, L.J. / Gruninger, R.J. / Wasney, G.A. / Blaukopf, M. / Baumann, L. / Lameignere, E. / Solomonson, M. / Brown, E.D. / Withers, S.G. / Strynadka, N.C.
External linksProc. Natl. Acad. Sci. USA / PubMed:25624472
MethodsX-ray diffraction
Resolution2.15 - 3.4 Å
Structure data

PDB-4x6l:
Crystal structure of S. aureus TarM in complex with UDP
Method: X-RAY DIFFRACTION / Resolution: 3.19 Å

PDB-4x7m:
Crystal structure of S. aureus TarM G117R mutant in complex with UDP and UDP-GlcNAc
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4x7p:
Crystal structure of apo S. aureus TarM
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-4x7r:
Crystal structure of S. aureus TarM G117R mutant in complex with Fondaparinux, alpha-GlcNAc-glycerol and UDP
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM

ChemComp-UD1:
URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-3YW:
(2S)-2,3-dihydroxypropyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside

Source
  • staphylococcus aureus subsp. aureus 21178 (bacteria)
KeywordsTRANSFERASE / Glycosyltransferase GT-B Retaining Wall teichoic acid

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