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TitleImproving target cell specificity using a novel monovalent bispecific IgG design.
Journal, issue, pagesMabs, Vol. 7, Page 377-389, Year 2015
Publish dateAug 11, 2014 (structure data deposition date)
AuthorsMazor, Y. / Oganesyan, V. / Yang, C. / Hansen, A. / Wang, J. / Liu, H. / Sachsenmeier, K. / Carlson, M. / Gadre, D.V. / Borrok, M.J. ...Mazor, Y. / Oganesyan, V. / Yang, C. / Hansen, A. / Wang, J. / Liu, H. / Sachsenmeier, K. / Carlson, M. / Gadre, D.V. / Borrok, M.J. / Yu, X.Q. / Dall'Acqua, W. / Wu, H. / Chowdhury, P.S.
External linksMabs / PubMed:25621507
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-4ub0:
New design for monovalent bispecific IgG through cysteine engineering of the CH1-CL interface
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab / knobs-into-holes / bispecific

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