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TitleHow pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Journal, issue, pagesFebs J., Vol. 282, Page 1225-1241, Year 2015
Publish dateMar 17, 2014 (structure data deposition date)
AuthorsGiardina, G. / Brunotti, P. / Fiascarelli, A. / Cicalini, A. / Costa, M.G. / Buckle, A.M. / di Salvo, M.L. / Giorgi, A. / Marani, M. / Paone, A. ...Giardina, G. / Brunotti, P. / Fiascarelli, A. / Cicalini, A. / Costa, M.G. / Buckle, A.M. / di Salvo, M.L. / Giorgi, A. / Marani, M. / Paone, A. / Rinaldo, S. / Paiardini, A. / Contestabile, R. / Cutruzzola, F.
External linksFebs J. / PubMed:25619277
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-4pvf:
Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / HYDROXYMETHYLTRANSFERASE / AAT-LIKE FOLD / ONE CARBON METABOLISM / 5-FORMYL-THF / METHYLASE / mitochondrial

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