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Structure paper

TitleSubunit disassembly and inhibition of TNF alpha by a semi-synthetic bicyclic peptide.
Journal, issue, pagesProtein Eng. Des. Sel., Vol. 28, Page 45-52, Year 2015
Publish dateJul 1, 2014 (structure data deposition date)
AuthorsLuzi, S. / Kondo, Y. / Bernard, E. / Stadler, L.K. / Vaysburd, M. / Winter, G. / Holliger, P.
External linksProtein Eng. Des. Sel. / PubMed:25614525
MethodsX-ray diffraction
Resolution2.85 Å
Structure data

PDB-4twt:
Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-38A:
(2,4,6-trimethylbenzene-1,3,5-triyl)trimethanol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsCytokine/inhibitor / Tumor Necrosis Factor-alpha / Bicyclo Compounds / Peptides / cytokine-inhibitor complex

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