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TitleStructure-based design of low-nanomolar PIM kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 25, Page 474-480, Year 2015
Publish dateDec 9, 2014 (structure data deposition date)
AuthorsIshchenko, A. / Zhang, L. / Le Brazidec, J.Y. / Fan, J. / Chong, J.H. / Hingway, A. / Raditsis, A. / Singh, L. / Elenbaas, B. / Hong, V.S. ...Ishchenko, A. / Zhang, L. / Le Brazidec, J.Y. / Fan, J. / Chong, J.H. / Hingway, A. / Raditsis, A. / Singh, L. / Elenbaas, B. / Hong, V.S. / Marcotte, D. / Silvian, L. / Enyedy, I. / Chao, J.
External linksBioorg. Med. Chem. Lett. / PubMed:25575657
MethodsX-ray diffraction
Resolution1.9 - 2.33 Å
Structure data

PDB-4x7q:
PIM2 kinase in complex with Compound 1s
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

PDB-4xhk:
PIM1 kinase in complex with Compound 1s
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-3YR:
2-(2,6-difluorophenyl)-N-{4-[(3S)-pyrrolidin-3-yloxy]pyridin-3-yl}-1,3-thiazole-4-carboxamide

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex

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