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Structure paper

TitleStructural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2)-Ia.
Journal, issue, pagesMbio, Vol. 6, Year 2015
Publish dateOct 22, 2014 (structure data deposition date)
AuthorsCox, G. / Stogios, P.J. / Savchenko, A. / Wright, G.D.
External linksMbio / PubMed:25564464
MethodsX-ray diffraction
Resolution1.482 - 1.73 Å
Structure data

PDB-4wqk:
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, apo form
Method: X-RAY DIFFRACTION / Resolution: 1.482 Å

PDB-4wql:
Crystal structure of aminoglycoside nucleotidylyltransferase ANT(2")-Ia, kanamycin-bound
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-KAN:
KANAMYCIN A / antibiotic*YM

Source
  • klebsiella pneumoniae (bacteria)
KeywordsTRANSFERASE / antibiotic resistance / aminoglycosides / kanamycin / nucleotidylyltransferase / adenylyltransferase / nucleotidyltransferase fold / alpha/beta protein / structural genomics / Center for Structural Genomics of Infectious Diseases / CSGID / National Institute of Allergy and Infectious Diseases / NIAID / transferase/transferase inhibitor / transferase-transferase inhibitor complex

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