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| Title | Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility. |
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| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 25, Page 529-541, Year 2015 |
| Publish date | Oct 21, 2014 (structure data deposition date) |
 Authors | Zak, M. / Liederer, B.M. / Sampath, D. / Yuen, P.W. / Bair, K.W. / Baumeister, T. / Buckmelter, A.J. / Clodfelter, K.H. / Cheng, E. / Crocker, L. ...Zak, M. / Liederer, B.M. / Sampath, D. / Yuen, P.W. / Bair, K.W. / Baumeister, T. / Buckmelter, A.J. / Clodfelter, K.H. / Cheng, E. / Crocker, L. / Fu, B. / Han, B. / Li, G. / Ho, Y.C. / Lin, J. / Liu, X. / Ly, J. / O'Brien, T. / Reynolds, D.J. / Skelton, N. / Smith, C.C. / Tay, S. / Wang, W. / Wang, Z. / Xiao, Y. / Zhang, L. / Zhao, G. / Zheng, X. / Dragovich, P.S. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:25556090 |
| Methods | X-ray diffraction |
| Resolution | 1.72 Å |
| Structure data |  PDB-4wq6: |
| Chemicals |  ChemComp-3TQ:  ChemComp-PO4:  ChemComp-EDO:  ChemComp-HOH: |
| Source |
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 Keywords | Transferase/Transferase inhibitor / Transferase-Transferase inhibitor complex |
homo sapiens (human)