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-Structure paper
Title | The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. |
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Journal, issue, pages | Mol. Cell, Vol. 57, Page 191-201, Year 2015 |
Publish date | May 3, 2014 (structure data deposition date) |
Authors | Reshetnyak, A.V. / Opatowsky, Y. / Boggon, T.J. / Folta-Stogniew, E. / Tome, F. / Lax, I. / Schlessinger, J. |
External links | Mol. Cell / PubMed:25544564 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-4pgz: |
Chemicals | ChemComp-NAG: ChemComp-CO: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Receptor Tyrosine Kinase / KIT receptor / IgSF / cancer / surface receptor |