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Structure paper

TitleEpoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 137, Page 86-89, Year 2015
Publish dateDec 22, 2014 (structure data deposition date)
AuthorsWong, F.T. / Hotta, K. / Chen, X. / Fang, M. / Watanabe, K. / Kim, C.Y.
External linksJ. Am. Chem. Soc. / PubMed:25535803
MethodsX-ray diffraction
Resolution2.33 Å
Structure data

PDB-4rzm:
Crystal structure of the Lsd19-lasalocid A complex
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

Chemicals

ChemComp-LSD:
Lasalocid A / antibiotic*YM

ChemComp-GOL:
GLYCEROL

ChemComp-FMT:
FORMIC ACID

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • streptomyces lasaliensis (bacteria)
KeywordsISOMERASE / NTF2-like fold / epoxide-opening cyclic ether formation / isomerization

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