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Title | Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 25, Page 75-82, Year 2014 |
Publish date | Aug 22, 2014 (structure data deposition date) |
![]() | Labadie, S. / Dragovich, P.S. / Chen, J. / Fauber, B.P. / Boggs, J. / Corson, L.B. / Ding, C.Z. / Eigenbrot, C. / Ge, H. / Ho, Q. ...Labadie, S. / Dragovich, P.S. / Chen, J. / Fauber, B.P. / Boggs, J. / Corson, L.B. / Ding, C.Z. / Eigenbrot, C. / Ge, H. / Ho, Q. / Lai, K.W. / Ma, S. / Malek, S. / Peterson, D. / Purkey, H.E. / Robarge, K. / Salphati, L. / Sideris, S. / Ultsch, M. / VanderPorten, E. / Wei, B. / Xu, Q. / Yen, I. / Yue, Q. / Zhang, H. / Zhang, X. / Zhou, A. |
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Methods | X-ray diffraction |
Resolution | 2.112 - 3.19 Å |
Structure data | ![]() PDB-4r68: ![]() PDB-4r69: |
Chemicals | ![]() ChemComp-NAI: ![]() ChemComp-EPE: ![]() ChemComp-W31: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-W13: |
Source |
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![]() | OXIDOREDUCTASE / nicotinamide adenine dinucleaotide |