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TitleMeclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5.
Journal, issue, pagesNucleic Acids Res., Vol. 43, Page 373-384, Year 2015
Publish dateJun 7, 2014 (structure data deposition date)
AuthorsHuang, Y. / Yan, J. / Li, Q. / Li, J. / Gong, S. / Zhou, H. / Gan, J. / Jiang, H. / Jia, G.F. / Luo, C. / Yang, C.G.
External linksNucleic Acids Res. / PubMed:25452335
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-4qkn:
Crystal structure of FTO bound to a selective inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-JMS:
2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid / antiinflammatory, inhibitor*YM

ChemComp-MN:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOxidoreductase/Oxidoreductase inhibitor / Jellyroll folding / Oxidoreductase-Oxidoreductase inhibitor complex

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