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Structure paper

TitleThalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
Journal, issue, pagesJ. Struct. Biol., Vol. 188, Page 225-, Year 2014
Publish dateOct 15, 2014 (structure data deposition date)
AuthorsHartmann, M.D. / Boichenko, I. / Coles, M. / Zanini, F. / Lupas, A.N. / Hernandez Alvarez, B.
External linksJ. Struct. Biol. / PubMed:25448889
MethodsX-ray diffraction
Resolution1.4 - 1.9 Å
Structure data

PDB-4v2y:
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-4v2z:
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Pomalidomide
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-4v30:
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Lenalidomide
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-4v31:
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Deoxyuridine
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4v32:
Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide, Y101F mutant
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-EF2:
S-Thalidomide / medication*YM

ChemComp-HOH:
WATER

ChemComp-Y70:
S-Pomalidomide

ChemComp-LVY:
S-Lenalidomide

ChemComp-DUR:
2'-DEOXYURIDINE

ChemComp-FLC:
CITRATE ANION

Source
  • magnetospirillum gryphiswaldense (magnetotactic)
KeywordsSIGNALING PROTEIN / TERATOGENICITY / AROMATIC CAGE / CC-4047 / POMALYST / CC-5013 / REVLIMID

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