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-Structure paper
Title | Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 10476-10485, Year 2014 |
Publish date | Oct 1, 2014 (structure data deposition date) |
![]() | Durham, T.B. / Klimkowski, V.J. / Rito, C.J. / Marimuthu, J. / Toth, J.L. / Liu, C. / Durbin, J.D. / Stout, S.L. / Adams, L. / Swearingen, C. ...Durham, T.B. / Klimkowski, V.J. / Rito, C.J. / Marimuthu, J. / Toth, J.L. / Liu, C. / Durbin, J.D. / Stout, S.L. / Adams, L. / Swearingen, C. / Lin, C. / Chambers, M.G. / Thirunavukkarasu, K. / Wiley, M.R. |
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Methods | X-ray diffraction |
Resolution | 1.24 - 1.62 Å |
Structure data | ![]() PDB-4wk7: ![]() PDB-4wke: ![]() PDB-4wki: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-CA: ![]() ChemComp-3PQ: ![]() ChemComp-HOH: ![]() ChemComp-EDO: ![]() ChemComp-3PU: ![]() ChemComp-3PW: |
Source |
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![]() | hydrolase/hydrolase inhibitor / Metalloprotease / Osteoarthritis / Inhibitor / hydrolase-hydrolase inhibitor complex |