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TitleThe Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
Journal, issue, pagesJ. Biol. Chem., Vol. 289, Page 36001-, Year 2014
Publish dateDec 12, 2013 (structure data deposition date)
AuthorsLee, E.F. / Dewson, G. / Evangelista, M. / Pettikiriarachchi, A. / Zhu, H. / Colman, P.M. / Fairlie, W.D.
External linksJ. Biol. Chem. / PubMed:25371206
MethodsX-ray diffraction
Resolution1.5 - 2.693 Å
Structure data

PDB-4cim:
Complex of a Bcl-w BH3 mutant with a BH3 domain
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-4cin:
Complex of Bcl-xL with its BH3 domain
Method: X-RAY DIFFRACTION / Resolution: 2.693 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / CELL DEATH

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