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TitleSmall Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation.
Journal, issue, pagesJ. Biol. Chem., Vol. 290, Page 3390-3404, Year 2015
Publish dateDec 24, 2010 (structure data deposition date)
AuthorsHorbelt, D. / Boergermann, J.H. / Chaikuad, A. / Alfano, I. / Williams, E. / Lukonin, I. / Timmel, T. / Bullock, A.N. / Knaus, P.
External linksJ. Biol. Chem. / PubMed:25368322
MethodsX-ray diffraction
Resolution1.96 Å
Structure data

PDB-3q4t:
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

Chemicals

ChemComp-TAK:
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Structural Genomics Consortium / SGC / Protein kinase

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