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Structure paper

TitleNegamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 111, Page 16274-16279, Year 2014
Publish dateSep 11, 2014 (structure data deposition date)
AuthorsOlivier, N.B. / Altman, R.B. / Noeske, J. / Basarab, G.S. / Code, E. / Ferguson, A.D. / Gao, N. / Huang, J. / Juette, M.F. / Livchak, S. ...Olivier, N.B. / Altman, R.B. / Noeske, J. / Basarab, G.S. / Code, E. / Ferguson, A.D. / Gao, N. / Huang, J. / Juette, M.F. / Livchak, S. / Miller, M.D. / Prince, D.B. / Cate, J.H. / Buurman, E.T. / Blanchard, S.C.
External linksProc. Natl. Acad. Sci. USA / PubMed:25368144
MethodsX-ray diffraction
Resolution3.09 Å
Structure data

PDB-4wf1:
Crystal structure of the E. coli ribosome bound to negamycin.
Method: X-RAY DIFFRACTION / Resolution: 3.09 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-NEG:
NEGAMYCIN

ChemComp-HOH:
WATER

Source
  • escherichia coli str. k-12 substr. mg1655 (bacteria)
  • escherichia coli (E. coli)
  • thermus thermophilus (bacteria)
KeywordsRibosome/Antibiotic / Protein biosynthesis / ribosomes / RNA / transfer / exit / peptidyl / 30S / 70S / 16S / ribosomal subunit / antibiotic / streptogramin / Ribosome-Antibiotic complex

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