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Title | Inhibitors of beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718). |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 9811-9831, Year 2014 |
Publish date | Sep 15, 2014 (structure data deposition date) |
Authors | Dineen, T.A. / Chen, K. / Cheng, A.C. / Derakhchan, K. / Epstein, O. / Esmay, J. / Hickman, D. / Kreiman, C.E. / Marx, I.E. / Wahl, R.C. ...Dineen, T.A. / Chen, K. / Cheng, A.C. / Derakhchan, K. / Epstein, O. / Esmay, J. / Hickman, D. / Kreiman, C.E. / Marx, I.E. / Wahl, R.C. / Wen, P.H. / Weiss, M.M. / Whittington, D.A. / Wood, S. / Fremeau, R.T. / White, R.D. / Patel, V.F. |
External links | J. Med. Chem. / PubMed:25363711 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-4rcd: |
Chemicals | ChemComp-3LL: ChemComp-IOD: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | Hydrolase/Hydrolase inhibitor / aspartyl protease / Alzheimer's disease / APP / amyloid precursor protein / brain / Hydrolase-Hydrolase inhibitor complex |