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TitleA nanobody modulates the p53 transcriptional program without perturbing its functional architecture.
Journal, issue, pagesNucleic Acids Res., Vol. 42, Page 12928-12938, Year 2014
Publish dateJun 19, 2014 (structure data deposition date)
AuthorsBethuyne, J. / De Gieter, S. / Zwaenepoel, O. / Garcia-Pino, A. / Durinck, K. / Verhelle, A. / Hassanzadeh-Ghassabeh, G. / Speleman, F. / Loris, R. / Gettemans, J.
External linksNucleic Acids Res. / PubMed:25324313
MethodsX-ray diffraction
Resolution1.924 Å
Structure data

PDB-4qo1:
p53 DNA binding domain in complex with Nb139
Method: X-RAY DIFFRACTION / Resolution: 1.924 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • lama glama (llama)
  • homo sapiens (human)
KeywordsApoptosis / transcription / Immunoglobulin fold / DNA binding

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