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-Structure paper
Title | Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 8503-8516, Year 2014 |
Publish date | Jun 6, 2014 (structure data deposition date) |
![]() | Fu, J. / Tjandra, M. / Becker, C. / Bednarczyk, D. / Capparelli, M. / Elling, R. / Hanna, I. / Fujimoto, R. / Furegati, M. / Karur, S. ...Fu, J. / Tjandra, M. / Becker, C. / Bednarczyk, D. / Capparelli, M. / Elling, R. / Hanna, I. / Fujimoto, R. / Furegati, M. / Karur, S. / Kasprzyk, T. / Knapp, M. / Leung, K. / Li, X. / Lu, P. / Mergo, W. / Miault, C. / Ng, S. / Parker, D. / Peng, Y. / Roggo, S. / Rivkin, A. / Simmons, R.L. / Wang, M. / Wiedmann, B. / Weiss, A.H. / Xiao, L. / Xie, L. / Xu, W. / Yifru, A. / Yang, S. / Zhou, B. / Sweeney, Z.K. |
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Methods | X-ray diffraction |
Resolution | 2.39 Å |
Structure data | ![]() PDB-4tot: |
Chemicals | ![]() ChemComp-P6G: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | ISOMERASE/ISOMERASE Inhibitor / Inhibitor / Complex / Cyclosporin / ISOMERASE-ISOMERASE Inhibitor complex |