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-Structure paper
Title | Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA. |
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Journal, issue, pages | Mol. Cell, Vol. 56, Page 541-550, Year 2014 |
Publish date | Sep 12, 2014 (structure data deposition date) |
Authors | Polikanov, Y.S. / Szal, T. / Jiang, F. / Gupta, P. / Matsuda, R. / Shiozuka, M. / Steitz, T.A. / Vazquez-Laslop, N. / Mankin, A.S. |
External links | Mol. Cell / PubMed:25306922 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-4w2i: |
Chemicals | ChemComp-MG: ChemComp-NEG: ChemComp-SF4: ChemComp-ZN: ChemComp-K: ChemComp-HOH: |
Source |
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Keywords | RIBOSOME/ANTIBIOTIC / Negamycin / antibiotic / 70S ribosome / inhibition of translation / miscoding / translocation inhibitor / 30S subunit with negamycin / mRNA / deacylated A- / P- / and E-site tRNAs of the 1st 70S ribosome in the ASU / Functional complex of bacterial 70S ribosome with antibiotic negamycin / 50S subunit of the 1st 70S ribosome in the ASU / RIBOSOME-ANTIBIOTIC complex |