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Structure paper

TitleDevelopment and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Journal, issue, pagesAcs Chem. Biol., Vol. 9, Page 2787-2795, Year 2014
Publish dateAug 15, 2014 (structure data deposition date)
AuthorsLamberto, I. / Lechtenberg, B.C. / Olson, E.J. / Mace, P.D. / Dawson, P.E. / Riedl, S.J. / Pasquale, E.B.
External linksAcs Chem. Biol. / PubMed:25268696
MethodsX-ray diffraction
Resolution2.41 - 2.42 Å
Structure data

PDB-4w4z:
Structure of the EphA4 LBD in complex with peptide
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

PDB-4w50:
Structure of the EphA4 LBD in complex with peptide
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

Chemicals

ChemComp-HEZ:
HEXANE-1,6-DIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-BU2:
1,3-BUTANEDIOL

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Protein-Inhibitor Complex / Ligand Binding Domain / Signal Transduction / Receptor-Tyrosine Kinase / Cyclic Peptide / EphA4 / Phage Display / TRANSFERASE-TRANSFERASE INHIBITOR complex

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