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Structure paper

TitleEvolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 159, Page 58-68, Year 2014
Publish dateJan 24, 2014 (structure data deposition date)
AuthorsMcKeown, A.N. / Bridgham, J.T. / Anderson, D.W. / Murphy, M.N. / Ortlund, E.A. / Thornton, J.W.
External linksCell(Cambridge,Mass. ) / PubMed:25259920
MethodsX-ray diffraction
Resolution1.7 - 2.701 Å
Structure data

PDB-4oln:
Ancestral Steroid Receptor 1 in complex with estrogen response element DNA
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-4ond:
Ancestral Steroid Receptor 2 DBD helix mutant - ERE DNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.253 Å

PDB-4oor:
Ancestral Steroid Receptor 2 DNA binding domain in complex with a steroid response element
Method: X-RAY DIFFRACTION / Resolution: 2.701 Å

PDB-4ov7:
Ancestral Steroid Receptor 2 DBD helix mutant - SRE DNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.701 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsTRANSCRIPTION/DNA / nuclear receptor zinc finger / transcription factor / steroid receptor DNA binding / estrogen receptor / TRANSCRIPTION-DNA complex / nuclear receptor DNA binding domain / zinc finger / coregulators / steroid receptor / DNA / Steroid Receptor DNA binding domain

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