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TitlePhenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease.
Journal, issue, pagesJ. Med. Chem., Vol. 57, Page 8086-8098, Year 2014
Publish dateAug 27, 2014 (structure data deposition date)
AuthorsSagong, H.Y. / Bauman, J.D. / Patel, D. / Das, K. / Arnold, E. / LaVoie, E.J.
External linksJ. Med. Chem. / PubMed:25225968
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-4w9s:
2-(4-(1H-tetrazol-5-yl)phenyl)-5-hydroxypyrimidin-4(3H)-one bound to influenza 2009 H1N1 endonuclease
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-3K1:
5-hydroxy-2-[4-(1H-tetrazol-5-yl)phenyl]pyrimidin-4(3H)-one

ChemComp-HOH:
WATER

Source
  • influenza a virus
Keywordstranscription/transcription inhibitor / CAP-SNATCHING / RNA BINDING PROTEIN / RNA BINDING PROTEIN-INHIBITOR COMPLEX / transcription-transcription inhibitor complex

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