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TitleBinding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Journal, issue, pagesCell Rep, Vol. 8, Page 1668-1676, Year 2014
Publish dateJul 21, 2014 (structure data deposition date)
AuthorsGao, P. / Zillinger, T. / Wang, W. / Ascano, M. / Dai, P. / Hartmann, G. / Tuschl, T. / Deng, L. / Barchet, W. / Patel, D.J.
External linksCell Rep / PubMed:25199835
MethodsX-ray diffraction
Resolution1.88 - 2.51 Å
Structure data

PDB-4qxo:
Crystal structure of hSTING(group2) in complex with DMXAA
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-4qxp:
Crystal structure of hSTING(G230I) in complex with DMXAA
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

PDB-4qxq:
Crystal structure of hSTING(S162A/Q266I) in complex with DMXAA
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

PDB-4qxr:
Crystal structure of hSTING(S162A/G230I/Q266I) in complex with DMXAA
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

Chemicals

ChemComp-1YE:
(5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / innate immunity / cGAMP Binding / Membrane

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