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Structure paper

Titlec-Src Binds to the Cancer Drug Ruxolitinib with an Active Conformation
Journal, issue, pagesPlos One, Vol. 9, Page e106225-e106225, Year 2014
Publish dateJul 25, 2014 (structure data deposition date)
AuthorsDuan, Y. / Chen, L. / Chen, Y. / Fan, X.G.
External linksPlos One / PubMed:25197973
MethodsX-ray diffraction
Resolution2.26 Å
Structure data

PDB-4u5j:
C-Src in complex with Ruxolitinib
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

Chemicals

ChemComp-RXT:
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile / medication, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / c-Src / Ruxolitinib / kinase / inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex

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