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Title | Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 7955-7970, Year 2014 |
Publish date | May 9, 2014 (structure data deposition date) |
Authors | Yoo, E. / Salunke, D.B. / Sil, D. / Guo, X. / Salyer, A.C.D. / Hermanson, A.R. / Kumar, M. / Malladi, S.S. / Balakrishna, R. / Thompson, W.H. ...Yoo, E. / Salunke, D.B. / Sil, D. / Guo, X. / Salyer, A.C.D. / Hermanson, A.R. / Kumar, M. / Malladi, S.S. / Balakrishna, R. / Thompson, W.H. / Tanji, H. / Ohto, U. / Shimizu, T. / David, S.A. |
External links | J. Med. Chem. / PubMed:25192394 |
Methods | X-ray diffraction |
Resolution | 2 - 2.1 Å |
Structure data | PDB-4qbz: PDB-4qc0: |
Chemicals | ChemComp-NAG: ChemComp-D80: ChemComp-HOH: ChemComp-XG1: |
Source |
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Keywords | RNA BINDING PROTEIN / Leucine rich repeat / Glycosylation / innate immunity / RNA recognition / ssRNA / RNA Binding / Secreted / Structure-based Ligand Design / TLR8 and TLR7 agonist / vaccine adjuvants / RNA Receptor / Antiviral and Antitumor Drug Binding |