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Title | Difluoro-dioxolo-benzoimidazol-benzamides As Potent Inhibitors of CK1 delta and epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation. |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 7933-7946, Year 2014 |
Publish date | Jun 30, 2014 (structure data deposition date) |
Authors | Richter, J. / Bischof, J. / Zaja, M. / Kohlhof, H. / Othersen, O. / Vitt, D. / Alscher, V. / Pospiech, I. / Garcia-Reyes, B. / Berg, S. ...Richter, J. / Bischof, J. / Zaja, M. / Kohlhof, H. / Othersen, O. / Vitt, D. / Alscher, V. / Pospiech, I. / Garcia-Reyes, B. / Berg, S. / Leban, J. / Knippschild, U. |
External links | J. Med. Chem. / PubMed:25191940 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-4tw9: |
Chemicals | ChemComp-SO4: ChemComp-HSJ: ChemComp-CL: ChemComp-NA: ChemComp-386: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / CK1delta / CK1epsilon / phosphorylation / small molecule inhibitor |