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TitleDiscovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.
Journal, issue, pagesACS Med Chem Lett, Vol. 5, Page 894-899, Year 2014
Publish dateJun 19, 2014 (structure data deposition date)
AuthorsYu, M. / Wang, Y. / Zhu, J. / Bartberger, M.D. / Canon, J. / Chen, A. / Chow, D. / Eksterowicz, J. / Fox, B. / Fu, J. ...Yu, M. / Wang, Y. / Zhu, J. / Bartberger, M.D. / Canon, J. / Chen, A. / Chow, D. / Eksterowicz, J. / Fox, B. / Fu, J. / Gribble, M. / Huang, X. / Li, Z. / Liu, J.J. / Lo, M.C. / McMinn, D. / Oliner, J.D. / Osgood, T. / Rew, Y. / Saiki, A.Y. / Shaffer, P. / Yan, X. / Ye, Q. / Yu, D. / Zhao, X. / Zhou, J. / Olson, S.H. / Medina, J.C. / Sun, D.
External linksACS Med Chem Lett / PubMed:25147610
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-4qo4:
co-crystal structure of MDM2 (17-111) with compound 16, {(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-(6-CYCLOPROPYLPYRIDIN-2-YL)PROPYL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-35S:
{(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-(6-cyclopropylpyridin-2-yl)propyl]-3-methyl-2-oxopiperidin-3-yl}acetic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLigase/Ligase inhibitor / MDM2 / p53 / protein-protein interaction / inhibitor / Ligase-Ligase inhibitor complex

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