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TitleEbola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1.
Journal, issue, pagesCell Host Microbe, Vol. 16, Page 187-200, Year 2014
Publish dateJul 18, 2014 (structure data deposition date)
AuthorsXu, W. / Edwards, M.R. / Borek, D.M. / Feagins, A.R. / Mittal, A. / Alinger, J.B. / Berry, K.N. / Yen, B. / Hamilton, J. / Brett, T.J. ...Xu, W. / Edwards, M.R. / Borek, D.M. / Feagins, A.R. / Mittal, A. / Alinger, J.B. / Berry, K.N. / Yen, B. / Hamilton, J. / Brett, T.J. / Pappu, R.V. / Leung, D.W. / Basler, C.F. / Amarasinghe, G.K.
External linksCell Host Microbe / PubMed:25121748
MethodsX-ray diffraction
Resolution3.153 Å
Structure data

PDB-4u2x:
Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus
Method: X-RAY DIFFRACTION / Resolution: 3.153 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • zaire ebolavirus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / eVP24 / importin alpha6 / immune antagonist

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