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-Structure paper
Title | Discovery of Type II Inhibitors of TGF beta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 183-196, Year 2015 |
Publish date | Dec 31, 2013 (structure data deposition date) |
![]() | Tan, L. / Nomanbhoy, T. / Gurbani, D. / Patricelli, M. / Hunter, J. / Geng, J. / Herhaus, L. / Zhang, J. / Pauls, E. / Ham, Y. ...Tan, L. / Nomanbhoy, T. / Gurbani, D. / Patricelli, M. / Hunter, J. / Geng, J. / Herhaus, L. / Zhang, J. / Pauls, E. / Ham, Y. / Choi, H.G. / Xie, T. / Deng, X. / Buhrlage, S.J. / Sim, T. / Cohen, P. / Sapkota, G. / Westover, K.D. / Gray, N.S. |
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Methods | X-ray diffraction |
Resolution | 2.393 Å |
Structure data | ![]() PDB-4o91: |
Chemicals | ![]() ChemComp-NG2: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Mitogen-activated protein kinase kinase kinase 7 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera / Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / TRANSFERASE-TRANSFERASE INHIBITOR complex |