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Title | Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A). |
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Journal, issue, pages | J. Med. Chem., Vol. 57, Page 6632-6641, Year 2014 |
Publish date | May 7, 2014 (structure data deposition date) |
Authors | Hu, E. / Chen, N. / Bourbeau, M.P. / Harrington, P.E. / Biswas, K. / Kunz, R.K. / Andrews, K.L. / Chmait, S. / Zhao, X. / Davis, C. ...Hu, E. / Chen, N. / Bourbeau, M.P. / Harrington, P.E. / Biswas, K. / Kunz, R.K. / Andrews, K.L. / Chmait, S. / Zhao, X. / Davis, C. / Ma, J. / Shi, J. / Lester-Zeiner, D. / Danao, J. / Able, J. / Cueva, M. / Talreja, S. / Kornecook, T. / Chen, H. / Porter, A. / Hungate, R. / Treanor, J. / Allen, J.R. |
External links | J. Med. Chem. / PubMed:25062128 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-4phw: |
Chemicals | ChemComp-ZN: ChemComp-SO4: ChemComp-2W1: ChemComp-HOH: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / Inhibitor / Phosphodiesterase / keto-benzimidazole / Hydrolase-Hydrolase Inhibitor complex |