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-Structure paper
Title | Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 5, Page 787-792, Year 2014 |
Publish date | Mar 28, 2014 (structure data deposition date) |
![]() | Ehara, T. / Irie, O. / Kosaka, T. / Kanazawa, T. / Breitenstein, W. / Grosche, P. / Ostermann, N. / Suzuki, M. / Kawakami, S. / Konishi, K. ...Ehara, T. / Irie, O. / Kosaka, T. / Kanazawa, T. / Breitenstein, W. / Grosche, P. / Ostermann, N. / Suzuki, M. / Kawakami, S. / Konishi, K. / Hitomi, Y. / Toyao, A. / Gunji, H. / Cumin, F. / Schiering, N. / Wagner, T. / Rigel, D.F. / Webb, R.L. / Maibaum, J. / Yokokawa, F. |
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Methods | X-ray diffraction |
Resolution | 2.09 - 2.65 Å |
Structure data | ![]() PDB-4pyv: ![]() PDB-4q1n: |
Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-2XF: ![]() ChemComp-DMS: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-PO4: ![]() ChemComp-2Y9: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / Renin inhibitor / 3 / 5-substituted piperidines / HYDROLASE INHIBITOR COMPLEX / Hydrolase / HYDROLASE-HYDROLASE INHIBITOR complex / Aspartic protease / angiotensin |