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Structure paper

TitleEngineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Journal, issue, pagesProtein Sci., Vol. 23, Page 1332-1340, Year 2014
Publish dateJun 24, 2014 (structure data deposition date)
AuthorsChen, P. / Deng, Y.L. / Bergqvist, S. / Falk, M.D. / Liu, W. / Timofeevski, S. / Brooun, A.
External linksProtein Sci. / PubMed:25043846
MethodsX-ray diffraction
Resolution2.64 - 2.85 Å
Structure data

PDB-4tuu:
Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

PDB-4tv3:
Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ML9:
2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Lipid kinase activity / ATPase activity / Surface Plasmon Resonance (SPR) / isothermal titration calorimetry (ITC). / TRANSFERASE/TRANSFERASE Inhibitor / TRANSFERASE-TRANSFERASE Inhibitor complex

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