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Structure paper

TitleStructure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Journal, issue, pagesNature, Vol. 511, Page 557-562, Year 2014
Publish dateJan 31, 2014 (structure data deposition date)
AuthorsDore, A.S. / Okrasa, K. / Patel, J.C. / Serrano-Vega, M. / Bennett, K. / Cooke, R.M. / Errey, J.C. / Jazayeri, A. / Khan, S. / Tehan, B. ...Dore, A.S. / Okrasa, K. / Patel, J.C. / Serrano-Vega, M. / Bennett, K. / Cooke, R.M. / Errey, J.C. / Jazayeri, A. / Khan, S. / Tehan, B. / Weir, M. / Wiggin, G.R. / Marshall, F.H.
External linksNature / PubMed:25042998
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-4oo9:
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-OLA:
OLEIC ACID

ChemComp-2U8:
Mavoglurant

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • enterobacteria phage t4 (virus)
KeywordsMEMBRANE PROTEIN / 7TM / receptor / G-protein / cysteine-S-acetamide

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